The FIRE Summit 2024
Permanent URI for this collectionhttp://hdl.handle.net/1903/33513
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Item DNA Aptamers against Parkinson's Disease Biomarker Alpha-Synuclein(2024) Cabrera Martin, Maria; Lynch, Margaret; Marin, Andrea; Saluja, Jasmine; Spirito, CatherineItem Impact on Removal of the fabF & fabH Genes on Bacteriophage Replication in Escherichia Coli(2024) Davis, Rose; Herbolsheimer, Sebastian; Schreiber, Samuel; Trieu, Amanda; O'Hara, JessicaItem Determining the Effect of the Removal of the Amino Acid Arginine on Viral Replication in E.coli(2024) Pattasseril, Nichelle; Plass, Julia; Etemad, Kasra; Mutziger, John; Alexandrian, Andre; O'Hara, JessicaItem Quantum Optimization for Solving NP-Hard Problems(2024) Dayal, Arnav; Kalidindi, Raghava; Kosuru, Sohan; Moosavi, Miles; Jabeen, ShabnabThe University of Maryland has a lot of resources that it seeks to ensure every student has easy access to, ranging from facilities like Wi-fi to basic safety measures such as streetlights. Ensuring these resources are properly distributed amongst campus can grow to be expensive considering the University’s 1,339-acre estate. This optimization algorithm aims to minimize the resources necessary to ensure the entirety of any given area is fully encompassed by whatever facility the user desires. Quantum optimization is the ideal way to accomplish this task as classical optimizers are unable to provide as efficient of a solution due to the risk of getting trapped in local minima and the significantly weaker processing ability. The poorer performance of the classical optimizer is demonstrated in our results.Item The Quantum Zeno Effect(2024) Haswell, Meg; Ramanathan, Nithika; Ketner, Hannah; Jabeen, ShabnamItem Viral Implications of the glyA gene in E. coli(2024) Sigalovsky, Nicole; Moronell, Gwen; Artemenko, Allison; Izara, Jamie; Ekbatani, OliviaItem Investigating the Effects of tyrB on Escherichia Coli and Bacteriophage Replication(2024) Soni, Aarushi; King, Connor; Schankel, Kayla; Narine, Justin; Karanth, Ritvik; O'Hara, JessicaItem Hybrid Quantum Vision Transformers for Particle Image Classification(2024) Christopher, Darwin; Mahendran, Smithi; Shah, Saloni; Tanjore, Sid; Jabeen, ShabnamItem Bias in AI: Skin Cancer Detection(2024) Zhang, Chris; Rodrigues, Rachel; Konka, Sanjana; Azobi, Gorgeous; Kramarczuk, KristinaItem One-Pot Ligation LAMP Assay to Detect miRNA-222: A Glioma Biomarker(2024) Pallavajjala, Roshni; Adane, Yedidya; Fernandes, Catarina; Kaiser, Jillian; Patel, Khushi; Spirito, CatherineMany cancer diagnostic methods are invasive, time-consuming, and expensive. Delayed cancer diagnosis can lower patient survival rates. PCR-based techniques that detect miRNA biomarkers in blood have been utilized as early screening tools for various cancers. As an alternative to PCR, we designed and optimized an isothermal amplification technique, Ligation Loop-Mediated Isothermal Amplification (Ligation LAMP) assay, to detect miR-222, an established biomarker that is found in elevated levels in the bloodstream of early-stage glioma patients. We designed colorimetric and fluorescent Ligation-LAMP assays and demonstrated their specificity and sensitivity in detecting miR-222. We are working on implementing our assay into a One-Pot system, using Thermally Responsive Alkane Partitions (TRAPs) and a strand displacement assay utilizing magnetic beads. We found that the Ligation LAMP assay is sensitive and specific to glioma biomarker miR-222 and different probe lengths for Strand Displacement did not have a significant impact on ligation. With these results, we can further improve the One-Pot assay to be more point-of-care.Item Effects of the aceE Gene on E. coli Growth and Bacteriophage Replication(2024) Lippert, Celia; Lynskey, Julie Anne; Lee, James; Dasgupta, Ruben; O'Hara JessicaItem Selecting DNA Aptamers Against Airway Mucin Proteins for Therapeutics and Diagnostics(2024) Savage, Colin; McDonald, Cyan; Shpilman, Zackary; Spirito, CatherineMucus is a viscous bodily fluid composed of mucin proteins, inorganic salts, and water. MUC5AC and MUC5B are the two mucin proteins that makeup airway mucus. Elevated levels of MUC5AC can indicate certain diseases, like asthma and Chronic Obstructive Pulmonary Disease (COPD). Current treatments for mucus-associated respiratory diseases include using enzymes and chemical agents to clear mucus buildup. These existing treatments are limited in their ability to selectively target specific mucin proteins within mucus. Our research aims to select DNA aptamers that bind to MUC5AC or MUC5B, within mucus samples. We are optimizing a One-Pot SELEX or in vitro selection methodology previously used by other researchers to select aptamers against MUC16. Selected DNA aptamers with high binding affinity and specificity can detect airway mucin proteins and deliver engineered proteases to cleave and destroy them.Item Quantum-Enhanced Forecasting: Leveraging Quantum Gramian Angular Field And CNNs for Stock Return Predictions(2024) Bapanapalli, Abhinav; Mahmud, Ateef; Nadig, Chiraag; Thakker, Krish; Jabeen, ShabnamPredicting stock price movements is a complex challenge faced by many traders and analysts. Our research leverages Quantum Gramian Angular Field (QGAF) transformations combined with Convolutional Neural Networks (CNNs) to classify stock price trends as "up" or "down." By transforming 1D time-series stock data into 2D images, we enable CNNs to extract features more effectively, showcasing the potential of quantum machine learning in financial forecasting.Item AI Bias in Facial Recognition Systems(2024) Metukuru, Akhil; Movva, Vineeth; Sun, Rick; Kramarczuk, KristinaItem EL33T H4X0R5?: Fearmongering and Biases in Cybercrime Journalism(2024) Zutchi, Aria; Hao, Emily; Le, Linh; Liu, Sydney; Kramarczuk, KristinaItem The Effect of the E.coli lysA Gene on Viral Replication(2024) Godnick, Bill; Pullmann, Evan; Searls, Olivia; Solomon, Mary; O'Hara, JessicaItem Fluorescent Cell-Free Biosensor to Detect Tuberculosis(2024) Amankwah, Amma; Connolly, Isabella; Kotoulek, Klara; Sembria, Maricka; Spirito, CatherineItem Development of a Cell-Free Heme Biosensor(2024) Ly, Andrew; Savage, Emily; Bansal, Navya; Herbert, Xan; Spirito, CatherineItem The Effect of the pykA gene on Escherichia coli Growth and Bacteriophage Replication(2024) Crump, Caroline; Ganoe, Grace; Liu, Megan; Plastino, Sofia; O'Hara, JessicaItem Investigating Effects of sucA Gene Knockout on E. coli Growth & Phage Replication(2024) Rakee, Ruthu; Hollander, Brooke; Rudra, Avani; Tudor, Dennis; Nadeem, Hafsah; O'Hara, Jessica