A. CHH amino acid sequences (cloned sequence and transcriptome isoforms) C. quinquedens MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSDCYSN LVFRQCMNDL 120 LLMEDFDQYA GRVQMVGRKK KKKK 144 DN365_c0_g1_i1 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i2 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i4 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i5 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i6 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i7 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 DN365_c0_g1_i8 MMAVLVMVCV FMYTLPNAHA RSAQGLRMER LLASLRGPSD TASPLGDFSG SSNQGSSSHP 60 LEKRQIYDTS CKGVYDRGLF SDLEHVCDDC YNLYRTSYVA SACRSNCYSN LVFRQCMNDL 120 LLMEDFDQYA RKVQMVGRKK 140 B. CHH clone and transcriptome isoform amino acid alignment Consensus MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i1 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i2 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i4 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i5 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i6 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i7 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 DN365_c0_g1_i8 MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 C. quinquedens MMAVLVMVCVFMYTLPNAHARSAQGLRMERLLASLRGPSDTASPLGDFSGSSNQGSSSHP 60 Consensus LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i1 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i2 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i4 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i5 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i6 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i7 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 DN365_c0_g1_i8 LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMNDL 120 C. quinquedens LEKRQIYDTSCKGVYDRGLFSDLEHVCDDCYNLYRTSYVASACRSDCYSNLVFRQCMNDL 120 Consensus LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i1 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i2 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i4 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i5 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i6 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i7 LLMEDFDQYARKVQMVGRKK---- 140 DN365_c0_g1_i8 LLMEDFDQYARKVQMVGRKK---- 140 C. quinquedens LLMEDFDQYAGRVQMVGRKK---- 140