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Title: Arbitrary Steering of Multiple Particles Independently in an Electro-Osmotically Driven Microfluidic System
Authors: Shapiro, Benjamin
Chaudhary, Satej
Type: Article
Keywords: Electro-osmotic actuation
fluid control
particle steering
robust control
Issue Date: Jul-2006
Publisher: IEEE
Citation: S.Chaudhary, B.Shapiro. Arbitrary Steering of Multiple Particles Independantly in an Electroosmotically Driven Microfluidic System. IEEE Transactions on Control Systems Technology, vol 14, issue 4, pg 669-680, July 2006.
Abstract: We demonstrate how to use feedback control of microflows to steer multiple particles independently in planar microfluidic systems driven by electro-osmotic actuation. This technique enables the handling of biological materials, such as cells, bacteria, DNA, and drug packets, in a hand-held format using simple and easy-to-fabricate actuators. The feedback loop consists of a vision system which identifies the positions of the particles in real-time, a control algorithm that computes the actuator (electrode) inputs based on information received from the vision system, and a set of electrodes (actuators) that create the required flow through electro-osmotic forces to steer all the particles along their desired trajectories and correct for particle position errors and thermal noise. Here, we focus on the development of control algorithms to achieve the steering of particles: vision system implementation, fabrication of devices, and experimental validation is addressed in other publications. In particular, steering of a single (yeast cell) particle has been demonstrated experimentally in our prior research and we have recently demonstrated experimental steering of three particles independently. In this paper, we develop the control algorithms for steering multiple particles independently and we validate our control techniques using simulations with realistic sources of initial position errors and thermal noise. In this study, we assume perfect measurement and actuation.
Required Publisher Statement: Copyright © [2006] IEEE. Reprinted from IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Maryland 's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
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