Quality of Service (QoS) of the implementation of an application can be defined as a function of the properties of the application and its implementation as observed by the user and/or the environment. Typical application and implementation properties include latency, throughput, jitter, and the level of resolution. Many of the current and pending most popular applications, such as multimedia, wireless sensing and communications, security and PEBBs, have intrinsic relevant QoS components. Recently, quality of service attracted a great of deal of attention in a number of research and development communities, and in particular, in the network and multimedia literature. However, until now synthesis and CAD research did not addressed how to design systems with quantitative QoS requirements. Our goal in this paper is to outline foundations and framework in which QoS system design trade-offs and optimization can be addressed. We first identify and state in synthesis-usable way two currently most popular approaches to Quality of Service treatment: Q-RAM and DScurve (demand/service). We discuss advantages and limitations of the two approaches. Next, we show how these two approaches can be combined in a new more comprehensive QoS framework. We also explain and illustrate using examples interaction between QoS and synthesis and compilation tasks. We conclude by identifying and discussing the future directions related to synthesis of QoS-sensitive systems.