With the continuing growth in the amount of genetic data, members of the bioinformatics community are developing a variety of data-mining applications to understand the data and discover meaningful information. These applications are important in defining the design and performance decisions of future high performance microprocessors. This paper presents a detailed data-sharing analysis and chip-multiprocessor (CMP) cache study of several multithreaded data-mining bioinformatics workloads. For a CMP with a three-level cache hierarchy, we model the last-level of the cache hierarchy as either multiple private caches or a single cache shared amongst different cores of the CMP. Our experiments show that the bioinformatics workloads exhibit significant data-sharing—50–95% of the data cache is shared by the different threads of the workload. Furthermore, regardless of the amount of data cache shared, for some workloads, as many as 98% of the accesses to the last-level cache are to shared data cache lines. Additionally, the amount of data-sharing exhibited by the workloads is a function of the total cache size available—the larger the data cache the better the sharing behavior. Thus, partitioning the available last-level cache silicon area into multiple private caches can cause applications to lose their inherent data-sharing behavior. For the workloads in this study, a shared 32MB last-level cache is able to capture a tremendous amount of data-sharing and outperform a 32MB private cache configuration by several orders of magnitude. Specifically, with shared last-level caches, the bandwidth demands beyond the last-level cache can be reduced by factors of 3–625 when compared to private last-level caches.