This study examined and the relative contributions of (a) gender, (b) perceived stress, (c) social support from family and significant other, and (d) positive and negative dimensions of religious coping to the prediction of the psychological health and meaning in life among Central American immigrants. Findings revealed that greater perceived stress by Latinas/ Latinos was predictive of psychological health and meaning in life. Social support from significant other also was predictive of presence of meaning in one's life. Negative religious coping, specifically reappraisal of God's powers was predictive of search for meaning in one's life.