The importance of the manufacturing shop design in the successful operation of a production system is well known and as a result, significant research has been devoted to this area. This paper reviews important literature in various aspects of manufacturing shop design including layout, material flow path design, and transporter fleet sizing and routing. In addition, the paper focuses on contributions to integration issues such as the design for operation of material handling systems, and the concurrent design of the shop layout and the transportation system. Research studies in these areas are critically examined, and emerging opportunities for research are identified.