The role of the arts within economic development is increasing as many cities attempt to replicate the success of the SoHo district in New York City. The SoHo paradigm is based on utilization of artists as sanitizing agents of former industrial districts in preparation for gentrification. This study examines SoHo and other case studies in which the arts are key components in redevelopment initiatives. The case studies are compared to the economic revitalization of the Hampden community in Baltimore City. The hypothesis states that an influx of artists and art-related businesses into Hampden was a catalyst for the current economic revitalization and that this clustering of artists and arts-related businesses indicates an economy of agglomeration. Data was collected through surveys, interviews, and secondary resources. The surveys were designed to collect data that would indicate why artists and business people settled in Hampden; whether a trend was occurring ; whether the location was beneficial to art careers or businesses; and if they perceived the arts as having a significant impact on Hampden. Results of the research indicate that a significant link exists between artists and the economic activity in Hampden; an agglomeration economy is implied, but not confirmed; and that the arts and economic development models employed by the Hampden community may represent a new combination of the models previously employed.