The 2011 Health Disparities Profiles examines key health indicators at the state level for different racial and ethnic populations in each of the 50 states, the District of Columbia, Guam, Puerto Rico and the US Virgin Islands. Twenty-two health indicators are presented, which highlight some of the key areas related to health disparities among different populations. It can be used as a reference for policymakers and program managers to identify areas where major health disparities exist in each state.