Community involvement in community-wide interventions is important for a variety of scientific, ethical, and pragmatic reasons. However, the specific meaning of community involvement depends on the details of how it is enacted. Katz et al. outline an ambitious effort to blend the science of randomized controlled trials (RCTs) with the processes of community-based participatory research (CBPR) in translational research. RCTs provide the science, while CBPR provides the processes of tailoring and implementation. Katz et al. offer a detailed example of how research might occur through the use of community portals and community health advisors as local advocates for the delivery of interventions. Their examples are rich and raise fundamental issues regarding the importance of CBPR and the role of local participation in translational research more generally.