A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins
A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins
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Date
2003
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Ranade, Koustubh and Hinds, David and Hsiung, Chao Agnes and Chuang, Lee-Ming and Chang, Mau-Song and Chen, Ying-Tsung and Pesich, Robert and Hebert, Joan and Chen, Yii-Der I and Dzau, Victor and Olshen, Richard and Curb, David and Botstein, David and Cox, David R and Risch, Neil (2003) A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins. American Journal of Hypertension, 16. pp. 158-162.
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Abstract
Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ~10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low–normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.