The NIAMS has approached the research challenges and opportunities in addressing health disparities by utilizing a broad array of strategies. We have a commitment to maintaining a diverse research portfolio - we invest in our numerous areas using many approaches. Basic research is continuing to uncover many of the most fundamental mechanisms of life and is elucidating strategies for conquering clinical challenges. We take the lessons of basic research and translate them to the clinical arena -- known as "bench to bedside" research. Conversely, research also moves from "bedside to bench," and clinical research can be very useful in providing clues to basic mechanisms. These basic/clinical interactions and translations have served to lay a strong foundation for the present and provide many research opportunities for the future. Research being supported by the NIAMS provides for better diagnosis and treatment, as well as potentially for prevention, of many of the most common, disabling, costly, and chronic diseases compromising life for the American people B diseases that often affect women and minorities disproportionately. Our specific strategies for addressing health disparities in research, research infrastructure, and community outreach are included within each of these sections below.