Net-Zero Energy building designs have become ubiquitous within modern sustainable city frameworks because of their ability to minimize adverse ecological impact, through the integration of energy efficiency principles with renewable energy generation sources. This study presents the key accomplishments and research methodology for the detailed modeling and techno-economic assessment of Net Zero energy homes, conducted in collaboration between the A. James Clark School of Engineering and the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL). The University of Maryland’s 2017 award-winning reACT virtual system has been used as a prototype for modeling and assessment efforts. By amalgamating elements of Model-based Systems Engineering design with NREL’s REopt optimization platform, the research aims to minimize system lifecycle costs for Net-Zero energy homes through the optimization of available generation resources, which will in turn proliferate and encourage the adoption of Net Zero Energy homes across global communities.