The real-time control in airport management can reduce delay cost and alleviate delay propagation in an airline network. In this study, a model is developed to determine holding decisions and departure policies to the ready departure flights, which have transfer passengers from late arrival flights. Optimization with downstream coordination (ODC) and optimization without downstream coordination (ONDC) are presented in the model. The results show that ODC and ONDC could reduce system total cost when flights are delayed, and ODC performs better than ONDC. The sensitivity analysis of the total cost to various inputs is also discussed. The results show that the system total cost varies with holding time, slack time, number of transfer passengers and headway.