University of Maryland DRUM  
University of Maryland Digital Repository at the University of Maryland

Digital Repository at the University of Maryland (DRUM) >
Theses and Dissertations from UMD >
UMD Theses and Dissertations >

Please use this identifier to cite or link to this item:

Authors: Dandin, Marc Peralte
Advisors: Abshire, Pamela A
Smela, Elisabeth
Department/Program: Bioengineering
Type: Dissertation
Sponsors: Digital Repository at the University of Maryland
University of Maryland (College Park, Md.)
Subjects: Electrical engineering
Biomedical engineering
Mechanical engineering
Keywords: CMOS
Issue Date: 2012
Abstract: This dissertation presents a body of work that addresses the two most pressing challenges in the field of integrated fluorescence sensing, namely, the design of integrated optical sensors and the fabrication of high-rejection micro-scale optical filters. Two novel enabling technologies were introduced. They are: the perimeter-gated single-photon avalanche diode (PGSPAD), for on-chip photon counting, and the benzotriazole (BTA)-doped thin-film polymer filter, for on-chip ultraviolet light rejection. Experimental results revealed that the PGSPAD front-end, fabricated in a 0.5 μm standard mixed-signal CMOS process, had the capability of counting photons in the MHz regime. In addition, it was found that a perimeter gate, a structural feature used to suppress edge breakdown in the diode, also maximized the signal-to-noise-ratio in the high-count rate regime whereas it maximized sensitivity at low count rates. On the other hand, BTA-doped filters were demonstrated utilizing three commonly used polymers as hosts. The filters were patternable, utilizing the same procedures traditionally used to pattern the undoped polymer hosts, a key advantage for integration into microsystems. Filter performance was analyzed using a set of metrics developed for optoelectronic characterization of integrated fluorescence sensors; high rejection levels (nearing -40 dB) of UV light were observed in films of only 5 μm in thickness. Ultimately, BTA-doped filters were integrated into a portable sensor, and their use was demonstrated in two types of bioassays.
Appears in Collections:Fischell Department of Bioengineering Theses and Dissertations
UMD Theses and Dissertations

Files in This Item:

File Description SizeFormatNo. of Downloads
Dandin_umd_0117E_13386.pdf85.21 MBAdobe PDF2837View/Open

All items in DRUM are protected by copyright, with all rights reserved.


DRUM is brought to you by the University of Maryland Libraries
University of Maryland, College Park, MD 20742-7011 (301)314-1328.
Please send us your comments