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Title: Characterization of Iron Oxide Nanoparticles in Structural Silk-elastinlike Protein Polymer
Authors: Shih, Jennifer
Advisors: Briber, Robert M
Department/Program: Material Science and Engineering
Type: Thesis
Sponsors: Digital Repository at the University of Maryland
University of Maryland (College Park, Md.)
Subjects: Materials Science
Keywords: iron oxide nanoparticles
silk elastin-like protein polymer
small angle neutron scattering
transmission electron microscopy
vibrating sample magnetometry
Issue Date: 2012
Abstract: The structure of silk elastin-like protein (SELP) block copolymers containing Fe3O4 magnetic nanoparticles are investigated. These materials have potential applications for hyperthermia cancer therapy. SELPs undergo a gel transition at physiological temperatures, which can be used to localize delivery of nanoparticles at tumor sites. Vibrating sample magnetometry (VSM), transmission electron microscopy (TEM), and small angle neutron scattering (SANS) are used to characterize the nanoparticles and the SELP-nanoparticle nanocomposite system. A series of nanoparticles with three different nominal diameters, 30, 50 and 80 nm, were added to 4 and 8 wt.% SELP samples. Different functionalities on the nanoparticle surface affect their interactions with SELP. The 50 nm nanoparticles in SELP exhibit chaining (linear association of the nanoparticles), while the 30 nm nanoparticles are too small and settle out of the polymer mesh and the 80 nm nanoparticles tend to cluster without any regard for SELP structure. The SELP concentration does not have a major affect on nanoparticle behavior in the nanocomposites.
Appears in Collections:Materials Science & Engineering Theses and Dissertations
UMD Theses and Dissertations

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