Now showing items 1-6 of 6
Highly Scalable Short Read Alignment with the Burrows-Wheeler Transform and Cloud Computing
Improvements in DNA sequencing have both broadened its utility and dramatically increased the size of sequencing datasets. Sequencing instruments are now used regularly as sources of high-resolution evidence for genotyping, ...
High Performance Computing for DNA Sequence Alignment and Assembly
Recent advances in DNA sequencing technology have dramatically increased the scale and scope of DNA sequencing. These data are used for a wide variety of important biological analyzes, including genome sequencing, comparative ...
Whole-genome sequence analysis for pathogen detection and diagnostics
This dissertation focuses on computational methods for improving the accuracy of commonly used nucleic acid tests for pathogen detection and diagnostics. Three specific biomolecular techniques are addressed: polymerase ...
Novel Methods for Metagenomic Analysis
By sampling the genetic content of microbes at the nucleotide level, metagenomics has rapidly established itself as the standard in characterizing the taxonomic diversity and functional capacity of microbial populations ...
Cellular Pattern Quantication and Automatic Bench-marking Data-set Generation on confocal microscopy images
The distribution, directionality and motility of the actin fibers control cell shape, affect cell function and are different in cancer versus normal cells. Quantification of actin structural changes is important for ...
A framework for discovering meaningful associations in the annotated life sciences Web
During the last decade, life sciences researchers have gained access to the entire human genome, reliable high-throughput biotechnologies, affordable computational resources, and public network access. This has produced ...